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Sunday 30 September 2012
Australians Surge in Quest to Build Quantum Computer
[unable to retrieve full-text content]Teams based at the University of New South Wales have made advances toward building a quantum computer, which could help tackle a new class of problems.
?Trust & Love? ? The Naked Convos | The Naked Convos
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My boyfriend and I started dating mid last year One day, I was playing games on his ipad when an email notification appeared, casually I clicked Inbox. I really wasn?t thinking when I started reading his email untl I got a rude shock. I was still emailing his ex who is in yankee. I know her cos we went to the school together. Like the email is nothing serious but he gave me the impression that they were no longer in touch. I remember recently when she came up in our conversation and I asked him when last he heard from her and he said last year sometime last year
Me, I don?t know how to keep things so I confronted him immediately. At first he was very mad that I shouldn?t be reading his email blab la bla?. Then he started saying he didn?t want to hurt me but they still keep in touch as casual friends. Efe, our relationship is no longer fun?What do you think?
Riri
Hello Riri,
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Relationships are basically about completely trusting and loving the person you are with.
Less than 100% love is like, less than 100% trust is suspicion.
Both of you violated one of the terms of a healthy happy relationship -Trust.? He lied, and you snooped.? And this has changed things for a very long time to come. He can?t say, ?I have never lied to you baby? and you can?t say ?Trust me baby?
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Efe, please advice me on how to handle my drama queen of a girlfriend. She?s very argumentative and aggressive. I am also a an aggressive person but I have mastered the art of calming myself down cos I tend to result to violence when I am upset.I sometimes tell her that if our roles were reversed, she the guy and my the babe in our relationship, I am sure she would be physically abusing me. And to make matters worse, when I try to calm her down or let her know that we aren?t exactly communicating during those heated moments, she starts saying condescending things like ?be a man and deal with your issues? or you are just looking for an escape route?.
It is just tough to be work things out in our relationship with this kind of behaviour. Bro, do you have any advice?
J
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Hello J,
I have been in such a relationship, to keep this sane during an argument, you try to say things in a way that will make your girlfriend calm down and have a dialogue> By communicating your feelings in very simple and honest terms, you expect her to not only hear you but also respond and reciprocate accordingly.
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By the time my relationship was ending, I learnt that my confusion on why my girlfriend at the time couldn?t just get it wasn?t necessary. I had come to learn that people like that do actually understand everything that was communicated to them but they don?t really care for the other person?s feeling. And a clear indication of this fact is that they continue to carry on their behaviour. Think about this, who wouldn?t really love to resolve their relationship problems in a quiet and matured way? Only that person who doesn?t care about the person they are in a relationship with.
-????????? Efe
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Hello everyone, please use the comment box and give some advice or share our own experience.
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As always, any email sent to?saturdayconvos@thenakedconvos.com?asking questions or sharing a secret will be treated discretely and only published as anonymous. Enjoy the rest of your weekend.
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As you may already know, The Naked Convos was one of the few international blogs?nominated at this years Black Weblog Awards. We were nominated in the Best New?Blog, Best Sex or Relationship and Best Blog Post Series categories. Now it?s
time to make the nominations count. It?s time to VOTE.
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Similar Posts:
- TRUST: A short story
- It Feels Like Love ? But Is It?
- Our Love Has Gone Cold
- Our Love is Gone??.
Source: http://www.thenakedconvos.com/trust-love/?utm_source=rss&utm_medium=rss&utm_campaign=trust-love
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Baltimore, MD 2011 Ford Shelby GT500 Used Coupe Glen Burnie, MD Annapolis, MD Bob Bell Ford/ Hyundai/ Kia for $47,995
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*The advertised price does not include sales tax, vehicle registration fees, finance charges, documentation charges, and any other fees required by law. We attempt to update this inventory on a regular basis. However, there can be lag time between the sale of a vehicle and the update of the inventory.
EPA mileage estimates are for newly manufactured vehicles only. Your actual mileage will vary depending on how you drive and maintain your vehicle.
Before purchasing this vehicle, it is your responsibility to address any and all differences between information on this website and the actual vehicle specifications and/or any warranties offered prior to the sale of this vehicle. Vehicle data on this website is compiled from publicly available sources believed by the publisher to be reliable. Vehicle data is subject to change without notice. The publisher assumes no responsibility for errors and/or omissions in this data the compilation of this data and makes no representations express or implied to any actual or prospective purchaser of the vehicle as to the condition of the vehicle, vehicle specifications, ownership, vehicle history, equipment/accessories, price or warranties. 2011 Ford Glen Burnie, MD
Source: http://www.bobbell.com/2011-Ford-Shelby-GT500-Baltimore-MD/vd/11854892
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iOS, Android once again grow market shares at RIM and Microsoft?s expense
NEW YORK (Reuters) - China said on Thursday that the disagreement over Iran's nuclear program had reached "a new, crucial stage," calling for Tehran to begin a new round of talks with world powers, something a U.S. official said could happen at some point. Chinese Foreign Minister Yang Jiechi made the comment after Israeli Prime Minister Benjamin Netanyahu made a speech drawing a "red line" for Iran's nuclear program on Thursday, despite a U.S. refusal to set an ultimatum, saying Tehran will be on the brink of a nuclear weapon in less than a year. ...
Source: http://news.yahoo.com/ios-android-once-again-grow-market-shares-rim-171556404.html
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Court of Appeals for the Federal Circuit tells Judge Koh to revisit Galaxy Tab 10.1 injunction
One of the hallmarks of the US judicial system is its seemingly inexhaustible system of appeals -- a system for which Samsung is likely most grateful at the moment. Its earlier entreaty to Judge Lucy Koh to have the Galaxy Tab 10.1 preliminary injunction lifted may have been denied, but the Court of Appeals for the Federal Circuit is giving the Korean company another bite at the Apple. That court has granted Samsung's request to have the injunction issue remanded so that the trial court can re-consider Samsung's motion to dissolve it. The ruling enables Samsung to argue that the injunction should be lifted because the jury failed to find infringement of the tablet design patent upon which the injunction is based. Will Judge Koh lift the ban? Perhaps, but we're pretty sure that the crowd from Cupertino will be doing plenty to prevent that from happening. Stay tuned.
Filed under: Tablets, Apple, Samsung
Court of Appeals for the Federal Circuit tells Judge Koh to revisit Galaxy Tab 10.1 injunction originally appeared on Engadget on Fri, 28 Sep 2012 15:16:00 EDT. Please see our terms for use of feeds.
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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/qvrnVB7uC_s/
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Saturday 29 September 2012
Feature: Lessons From a Gaming Expo - Nintendo Life
A rite of passage
For many gamers, this hobby of ours is about more than just buying and playing games, but also about hitting up expos, which are havens of gaming and related shenanigans. We?ve spent the past few days soaking up the sights and sounds at the Eurogamer Expo in London, and we?ve had some important gaming life lessons reaffirmed in the process.
If you hype it, they will come
Apparently ZombiU is here
Nintendo secured a good spot at the Eurogamer Expo with the Wii U section ? though some 3DS demos were thrown in ? being one of the first that attendees see. What?s most fascinating is that ZombiU has its own separate queue, with those eager zombie victims waiting up to two hours to play one game, when the Wii U area as a whole has various titles on offer. Even better, this title?s queue is often longer than the Wii U equivalent, showing that it?s dominating gamer?s attentions and, maybe affections.
We shouldn?t be surprised, as Nintendo of Europe has gone to great lengths to hype the title as a must-have Wii U exclusive. We even have the ZombiU console bundle, which doesn?t include Nintendo Land but comes with a Pro Controller as an extra incentive. The demo area itself is bigger than any other Nintendo title on show, even New Super Mario Bros. U. Most expo fans will be trying it out for the first time, but lots of coverage and the coveted ?18? rating mean that it gets top billing.
Still, Wii U has been quite well hyped overall, featuring as one of the most popular attractions on show. Does hype equal brilliance? Not long until we find out.
People wear the strangest things
Mike's caught one
Ah, cosplay. We all have heroes, some of whom exist as pixels or polygons, and dressing up as them is the greatest complement we can pay ? apart from filling their owner?s wallets by buying the games, of course. There are official mascots of course, including the Super ?God they?re tall? Mario Bros. pictured in our photos from the Eurogamer Expo show floor, but they don?t count because they?re being paid to dress up and amuse us all. Real cosplay is reserved for the unpaid enthusiasts, who often make their own outfits, with mixed results.
Some outfits are rather good, making the distinction between paid-up pros and good cosplayers tricky, with mini-celebrities forming in the process. One dressed as Lara Croft, for example, drew quite a crowd keen to take pictures, but we weren?t sure if she was linked to the publisher or game. We also met a walking Pikachu, who ironically informed us that she was, exclusively, an Xbox gamer; like we said, people wear the strangest things.
Ultimately cosplay is all about being a big fan and, maybe, a bit of a show-off. The Nintendo Life staff have debated whether a full pre-prepared outfit for hire counts, but let's keep things simple and say they are cosplay. It?s such a phenomenon that YouTube videos go viral, and expos often have photo-booths where attendees can pose and get a memento in front of an official background. If you decide to go cosplay, make sure you go all the way, like the pictured Pidgeot posing with our very own Mike Mason.
If you need StreetPass puzzle pieces, look no further
Get your hits here
At the Eurogamer Expo there?s a rather nice area with big comfy seats, rather conveniently called the ?Nintendo Life StreetPass Zone?. While it may be tricky to pick up many StreetPass hits where you live, wherever you are, events like these are a bonanza of hits, cool Mii characters and funky hats. For some of us desperate for pink puzzle pieces, it?s been a revelation.
If you can bear the thought of repeatedly clearing out hits from the StreetPass plaza, ten at a time of course, you?ll quite possible turn your woefully empty puzzle panels into cool 3D dioramas. Wherever these magical expo gamers got all of their pink puzzle pieces ? maybe at yet another event ? you may as well grab them while you can. In our experience it?s possible to pick up over 100 Mii chums, easily more, and it becomes an obsessive mini-game in its own right.
Pro tip for this: don?t forget to hold the R button to speed up the animations. If you don?t, then it?ll take you a long time to populate the plaza.
Those are three things that are inevitable at any gaming expo, and an experience for those trying one out for the first time. If you?ve been to gaming or technology events, tell us all about it in the comments below.
Source: http://www.nintendolife.com/news/2012/09/feature_lessons_from_a_gaming_expo
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Georgia Southern University Student Wins Muhammad Ali Writing Award for Ethics
Georgia Southern University senior Evin Hughes has won the first ever Muhammad Ali Writing Award for Ethics. The award, co-sponsored by the Muhammad Ali Center and the Norman Mailer Center and Writers Colony, in partnership with the National Council of Teachers of English (NCTE), is given to the outstanding college student whose writing reflects Muhammad Ali?s legacy of living a life dedicated to high ethical standards.
Lonnie and Muhammad Ali, and director, screenwriter, and producer Oliver Stone will present Hughes the award and a check for $10,000 at the Norman Mailer Center?s fourth annual benefit gala on Thursday, October 4, in New York City. Actor Alec Baldwin and Tina Brown of Newsweek Magazine and The Daily Beast.com will host the event, which celebrates renowned and emerging writers alike. Hughes, a Swainsboro, Georgia native, will also receive a week- long writing workshop next summer at the Mailer Center in Provincetown, Massachusetts, travel and hotel accommodations and tickets for the Gala.
The essay by the Georgia Southern dual major in Information Technology and Writing and Linguistics, emerged as the winner among eight semi-finalists and four finalists from such universities as Columbia, Georgetown, Oregon State, George Washington, Notre Dame and Alabama.
The three judges who read his prize-winning essay, ?Float like a Plane, Sting Like a Bomb: The Ethics of U.S. Drone Attacks,? included noted author and Nobel Peace Prize winner Dr. Elie Wiesel. In his nearly 5,000 word-winning entry, Hughes wrote about the harm of drones as weapons in ?the war on terror? and of a hopeful new future devoid of the violence created by drones.
The writers were judged on their understanding of the ethical issue posed in their essay, as well as for original thinking and insight, effectiveness in presenting a point-of-view and achieving an overall emotional or intellectual effect.
?This recognition of Evin Hughes reinforces the power of writing,? said Georgia Southern professor Phyllis Dallas who encouraged him to enter the contest.
?We faculty in Writing and Linguistics know that writing can affect the world, whether it is a poem or story that captures for its reader the beauty of language or an insight or emotion that leaves the reader knowing, as C.S. Lewis wrote, that we are not alone; or whether it is a finely crafted essay like Evin's that brings together his ethics, his critical analysis of a subject, and his synthesis of the research and writing of others to articulate an argument that asks its reader to consider and see their world anew and to question how to achieve peace and social justice.?
Donald Lassere, president and CEO of the Muhammad Ali Center said, ?The Ali Center is so proud of Evin and the rest of the student finalists and honorees being recognized at the Norman Mailer Center?s Gala. ?This has been an outstanding partnership for the Ali Center and it has afforded us another opportunity to share Muhammad?s legacy with the younger generation which Muhammad and Lonnie care so much about.?
The Norman Mailer Center is an educational non-profit dedicated to supporting and celebrating those writers who challenge the status quo and surprise their audiences. ?The Muhammad Ali Center?s mission is to preserve and share the legacy and ideals of Muhammad Ali and the National Council of Teachers of English is devoted to improving the teaching and learning of English and the language arts at all scholastic levels.
CLICK HERE To read Evin Hughes' prize-winning essay.?
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Source: http://news.georgiasouthern.edu/viewArticle.php?id=2303
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Wal-Mart, EB Games, Toys R Us Canada Gaming Deals: September ...
Toys R Us is easily the big winner this week with their ?Lowest Prices of the Season? event. Not only do they offer a free game and $20 off of a Wii, they also bring back their buy 1, get 1 40% off.
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Toys R Us
Free Nintendo Select with Wii New Super Mario Bros Console ? $129.99 (save $20)
Free copy of Jak and Daxter Collection, Eyepet and Friends, Twisted Metal, Ico and Shadow of the Colossus Collection, or Gran Turismo 5 XL Edition free with PS3 160GB Console ? $249.99
Modern Warfare 3 ? $39.99 (save $20)
Call of Duty: Black Ops ? $29.99 (save $10)
Modern Warfare 2 ? $19.99 (save $10)
Buy 1, Get 1 40% off on all $19.99 or higher games
20% off all video games accessories (excludes Kinect, Ps3 3D Display, Skylanders, network cards)
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EB Games
Fifa Soccer (Vita) ? $29.99 (save $10)
Persona 4 Arena ? $49.99 (save $10)
F1 2011 ? $29.99 (save $10)
Max Payne 3 ? $29.99 (save $30, October 1st ? 14th)
Offers Begin October 1st:
Lollipop Chainsaw ? $39.99 (save $20)
Battlefield: Bad Company 2 Ultimate Edition ? $19.99 (save $20)
Tiger Woods PGA Tour 13 ? $39.99 (save $20)
The Sims 3 (consoles) ? $19.99 (save $10)
Need For Speed: The Run ? $19.99 (save $10)
Mass Effect 3 ? $29.99 (save $10)
Max Payne 3 ? $29.99 (save $30)
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Superstore
NHL 13 ? $54.99 (save $5)
$50 gift card with PlayStation Vita purchase (coupon in the flyer)
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Wal-Mart
3 Character Decals with Resident Evil 6 purchase ? $59.83
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You May Also Like:
October 2012 New Releases
November 2012 New Releases
5 October 2012 Games You Have To Play (Part 1)
Nintendo Wii U Launch Line Up Detailed By Nintendo
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Source: http://trendygamers.com/2012/09/28/walmart-toys-us-eb-games/
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Friday 28 September 2012
Building a Bat Cave to Stop a Killer
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Source: http://www.nytimes.com/slideshow/2012/09/25/science/25Bats.html?partner=rss&emc=rss
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Snedeker to get early baptism in Ryder Cup
MEDINAH, Ill. (AP) ? Davis Love III sent out his hottest player. Jose Maria Olazabal went with his strongest teams. The Ryder Cup captains had the same objectives Thursday when they announced their teams for the opening sessions at Medinah.
Win points, the sooner the better.
"We have to go for it," Olazabal said. "I know we are playing away. The crowds are going to be on their side. They set up the course to their liking. At the end of the day, you have to make a bunch of birdies out there to win points. So just send the best players out there and see if they can perform well, and manage to win those points."
The foursomes lineup would seem to favor Europe.
Graeme McDowell and Rory McIlroy, the best player in golf, will lead off Friday morning against Jim Furyk and Brandt Snedeker, who is coming off a sterling four weeks that led to his Tour Championship win five days ago and the FedEx Cup title.
Snedeker describes himself as "jumpy," and Love found it important to get his fastest player out early.
"We wanted to get Brandt going," Love said.
In doing so, he became the third straight American captain to send out a Ryder Cup rookie in the leadoff match. Dustin Johnson was in the opening match at Wales, and Anthony Kim went out first at Valhalla. Both of them played with Phil Mickelson.
Mickelson is in the second game with Keegan Bradley, and they face the tough task of trying to be the first team to beat Luke Donald and Sergio Garcia, who are 4-0 in foursomes. Garcia has never lost in alternate shot. His record is 8-0-1.
"They are two very good players and it will be a tough match, but they are also two players that sometimes might not always hit it straight," Garcia said. "But we are just going to focus on our own games and hopefully we can win the point for Europe."
Bradley referred to Garcia and Donald as "legends in the Ryder Cup."
It will be the first time since 1995 that the Americans did not have either Mickelson or Tiger Woods in the leadoff match. Woods is the anchor this time with Steve Stricker, with whom he has a 6-2 record in the Ryder Cup and Presidents Cup. Their last two outings, however, ended badly ? a 6-and-5 loss to Donald and Lee Westwood at Wales in 2010, and a record 7-and-6 loss to Adam Scott and K.J. Choi in the Presidents Cup last November.
Woods and Stricker will play Ian Poulter and Justin Rose. Poulter is 8-3 in the Ryder Cup, though two of those losses were to Woods in team matches. Both of those matches were fourballs, where Woods has a stronger record.
Woods and Rose share the same swing coach in Sean Foley.
"There are no easy games in the Ryder Cup, but from a crowd perspective, if we do manage to go out there and get a point, it could be one of those huge swing-and-momentum moments," Rose said. "I think we go into this game with nothing to lose."
In the third slot are Westwood and Francesco Molinari against Zach Johnson and Jason Dufner, the third American rookie who will be in the opening session.
Both captains said all week the tough part would be figuring out who to leave out ? every player at Medinah is inside the top 35 in the world. Olazabal elected to bench Paul Lawrie, Martin Kaymer, Peter Hanson and Nicolas Colsaerts, the only rookie on Europe's side. Love sat out the pairing of Webb Simpson and Bubba Watson, and Dustin Johnson and Matt Kuchar.
"We have four on the bench. We're going to have to get them in the game," Love said.
Love said he would see how the matches progressed Friday morning before deciding on his next move for fouballs in the afternoon, though he sounded resolved to stick with the plan he has mapped out for the Americans, who have lost six of the last eight times in the Ryder Cup. And the North Carolina alum even mentioned a basketball coaching great.
"Dean Smith just ran his offense and he ran it and he ran it and he ran it until the game was over; and I think that's what we are going to do," Love said. "We have got a plan, we have some great players and we are just going to let them play until we run out of holes. I think everybody around me seems to feel like we have a pretty good plan."
Source: http://news.yahoo.com/snedeker-early-baptism-ryder-cup-221415060--golf.html
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Oregon Dressage Society News and Announcements ? TICKETS ...
Article source: Dressage-News.com
WEST PALM BEACH, Florida, Sept. 26?Tickets for the World Dressage Masters Palm Beach scheduled for next January went on sale Wednesday.
Wellington Classic Dressage that is organizing the event did not name any riders for the CDI5* at the Jim Brandon Equestrian Center Jan. 24-26, the same venue that hosted the ?100,000 (US$128,500) event the past two years.
Individual tickets at A and C sections of the arena are offered at prices from $225 to $265 for all days of the compettion.
Tables range from $6,500 to $7,500 for eight seats and $4,500 for four seats, including all food and beverages.
International Polo Club Palm Beach is handling ticket sales;?reservations can be made at 561-282-5334.
Palm Beach is one of the venues for the WDM series that in previous years has included Munich, Germany, Falsterbo, Sweden and Hickstead, England. The calendar for 2013 has not yet been announced.
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No home address on r?sum? - Business Management Daily
Q. I have received several r?sum?s that do not include a home address. Is this a red flag? ? L.Y., New York
A. Not necessarily. While some em??ployers may view such r?sum?s as being incomplete or be concerned that the applicants are trying to hide something, there are several good reasons why an individual may choose to leave his or her home address off a r?sum?.
1. Fear of disqualification based on location. Some employers admit that they prefer local candidates be??cause they?re worried that employees who have long commutes will have poor attendance records, will burn out sooner, or will leave as soon as they find something closer to home. Keep in mind that the applicant may be willing to relocate or could thrive despite a long commute.
2. Fear of bias based on location. Applicants may fear that stereotypes about low-income or predominantly minority neighborhoods could hurt their chances of being called.
3. Identity theft/privacy concerns. Individuals may be trying to limit the amount of personal information they give out.
4. Applicant is homeless, is living at a shelter, or is a victim of domestic abuse and is living at a safe house.
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Index ranks Idaho education 15th in the country based on options for ...
The Center for Education Reform has given Idaho a No. 15 ranking in its Parent Power Index.
The Center for Education Reform (CER), a Washington, D.C.-based organization dedicated to assisting states with education concerns geared toward choice in education and accountability, has released what it calls the ?Parent Power Index,? ranking states on parents? ability to choose a quality education for their children.
CER uses several factors in rating each state, including charter schools, online learning, teacher quality, school choice, as well as whether or not the state?s governor is pro-reform, which Idaho Gov. Butch Otter is.
The ratings are from 0-100 percent and Idaho ranks No. 15 with an index rating of 71 percent.
The index, in its summary of Idaho, also mentions that the Gem State ranks in the top five ?as judged by the key elements of digital learning and informing parents of their options, which includes charter schools.?
It also makes reference to propositions 1, 2 and 3?the referendums opposing Superintendent of Public Instruction Tom Luna?s education reforms?saying that an effort is under way to improve teacher quality should the opposition to the laws fail to repeal them.
Melissa McGrath, communications director for the state Department of Education, says it?s not a surprise to see Idaho ranked where it is in the index. ?We are proud of the many ways in which Idaho?s education system now empowers parents and families to make the best educational choices for their children.
?It is not surprising to us that Idaho would rank high in this index. I believe we will rank even higher if the report takes into account other parts of Students Come First, including the fact that now all parents can provide input in teacher and principal job evaluations,? she said.
Rep. Reed DeMourdant, R-Eagle, a member of the House Education Committee, said school choice, one of the factors used in the CER index, is vital in education.
?School choice is so important for our state. It has certainly provided lots of options that our kids never had and I think we need to continue and expand and provide opportunities for our parents out there to go out and create the schools that they need,? he said. ?What that means is we need to look at successful models in our state that are proven, we need to be able to replicate those easier, and we don?t have that ability today.?
DeMourdant also says that funding equalization for charter schools would play a large role in expanding school choice and options for parents. ?I believe we need to look at bonding equalization, bond levy equalization. I believe our charter schools ought to be able to participate in that as well in the same way that our traditional schools get bond levy equalization.?
While the Eagle lawmaker believes that Idaho?s education reforms are rather small compared to what can be done in the future concerning education reform, he is a proponent of incorporating some data-based models to make even greater strides in the K-12 public education system.
?I think we?re just scratching the surface. There are so many things that we can do for our kids in terms of using data to help drive that individual student?s education,? said DeMourdant. ?Today education is so much a group event, meaning that it is a teacher in front of a classroom lecturing and half the kids in the class may or may not be ready for that lecture. Data allows us to individualize that education by student.?
DeMourdant predicts that education reform in Idaho is just scratching the surface of what can be accomplished with student performance and achievement. ?As I look at innovative things that are being done around the nation to really provide individualized instruction for each student, data is a critical aspect of that and I think there are some great tools we can provide our teachers so they can start to customize the curriculum by student. That?s where I think we?re going to go next with education.?
The CER Parent Power Index ranks Indiana as the top state with a grade of 84 percent. Utah is the only neighboring state to Idaho with a top 10 ranking, coming in eighth at 75 percent.
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Thursday 27 September 2012
Jerome Horwitz dies at 93; developed potent anti-AIDS drug AZT
Jerome Horwitz, a medical researcher at Wayne State University in Detroit, had spent more than a decade developing a drug he hoped would work against cancer. But the compound failed to help the lab mice he tested it on, so in 1970 he "dumped it on the junk pile," wrote up his disappointing findings and moved on. He didn't bother applying for a patent.
What Horwitz didn't know was that the drug ? AZT ? was destined for success.
Almost 20 years after he had begun his work, scientists at the National Cancer Institute discovered AZT slowed the development of what had been thought to be an untreatable scourge, AIDS. In 1987, AZT became the first drug approved by the Food and Drug Administration for use against the disease caused by the human immunodeficiency virus, HIV.
The drug company that patented and marketed AZT helped establish a chair at Wayne State in Horwitz's name, but the chemist never shared a penny of the billions of dollars made because of his work. As he told the Chronicle of Higher Education many years later, "if I was ever bitter, it's long since passed" because of the millions of lives AZT has saved.
Once described as "one of academe's most under-recognized inventors," Horwitz died Sept. 6 in West Bloomfield Township, Mich. He was 93 and had heart problems, said his wife, Sharon Horwitz.
Horwitz "didn't have a patent, he didn't make money, but there is no question that what he did really dramatically accelerated the development of anti-retroviral drugs," Dr. Paul Volberding, director of the AIDS Research Institute at UC San Francisco, said this week. "It's impossible to be sure, but it would have taken a considerably longer time without his pioneering work."
When AZT made headlines in the 1980s, Horwitz briefly held the spotlight: People magazine named him one of the 25 most intriguing people of 1986 and he appeared on television news shows.
AZT was a controversial therapy because of its harsh side effects and prohibitive price ? about $8,000 a year. It has largely been replaced by less toxic drugs. But Horwitz developed two other drugs that have remained in the anti-AIDS/HIV arsenal, including dideoxycytidine, the second drug approved for AIDS patients, and stauvudine.
Horwitz also created a solution called X-Gal that is widely used to identify proteins.
"I didn't patent it ? story of my life," he told the Chronicle upon his retirement from Wayne State in 2005.
Horwitz was in his 80s when he shared in a five-year, $900,000 grant from the National Cancer Institute to refine drugs capable of treating solid tumors. That work led to Horwitz's first royalty check at 86.
Born in Detroit on Jan. 16, 1919, Horwitz was the son of a businessman who sold poultry. Disinclined to spend his life cleaning up chicken coops, he found his own path early in his teens, when he read "Microbe Hunters" by Paul de Kruif, a 1926 classic about groundbreaking scientists. "A light bulb went on," Horwitz recalled in the Detroit News in 2001. "I knew what I wanted to do."
He graduated with a degree in chemistry from the University of Detroit in 1942, earning a master's there two years later. Barred from World War II service because of high school football injuries, he went on to the University of Michigan and obtained a doctorate in chemistry in 1948.
In 1951, he joined the Illinois Institute of Technology, where he was part of a team developing solid rocket fuels for the Navy. He did not enjoy working with explosive materials, however, and in 1955 returned to Detroit to work at what became the Michigan Cancer Foundation. It is now called the Barbara Ann Karmanos Cancer Institute at Wayne State University.
In addition to his wife, Horwitz is survived by two daughters and five grandchildren.
In 1964, with the war on cancer in full swing, many scientists were randomly pulling drugs off the shelf to test their potential as anti-cancer agents, but Horwitz found this approach intellectually unsatisfying. He wanted to analyze the cancer cells and design a drug that would disrupt their growth.
Knowing that the cells divide using raw materials called nucleosides, he created what he called "fraudulent nucleosides" that were so similar to the real thing the cell would be tricked into using them. The fakes, he theorized, would gum up the cell's replication machinery and halt the development of the tumor.
Horwitz was ahead of his time in his approach, now called "rational drug design." Instead of trial-and-error, rational drug designers create a drug for a specific biological target, such as a cancer cell.
"He was able to take his scientific understanding and say ... 'I am going to devote my life to design a therapy that will strike at the heart of the disease,' " said Wei-Zen Wei, a longtime colleague and associate director at the Karmanos Cancer Institute. "At the time it was risky. He took a chance."
When Horwitz tested AZT, or azidothymidine, on leukemic mice, nothing happened. He admitted defeat and didn't think about it again until the mid-1980s, when scientists were randomly testing drugs in a frantic search for one that would combat AIDS.
At the National Cancer Institute, a group of researchers found the compound curbed the activity of HIV, a strange virus from a family known as retroviruses. Retroviruses were barely known at the time of Horwitz's work on the drug.
Horwitz learned that AZT had come back to life when a colleague pointed out a report on the results published by the researchers in 1985.
"My colleagues and I said that we had a very interesting set of compounds," he told the New York Times in 1986, "that were just waiting for the right disease."
elaine.woo@latimes.com
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UPDATE 1-NFL-Refs' union and league make progress in talks, source says
* "Economic gaps" remain
* Anger over missed call Monday night
Sept 26 (Reuters) - The NFL and locked-out referees have made progress in contract negotiations, a source close to the referees' union said on Wednesday, as hopes rise the two sides can strike a deal in time for officials to be back on the field for this weekend's games.
An agreement would come amid mounting criticism of the National Football League after a widely panned touchdown call by replacement referees gave the Seattle Seahawks a victory over the Green Bay Packers on Monday.
The furor appears to have given fresh impetus to talks that on Tuesday had direct input from team owners for the first time, according to the source close to the NFL Referees Association.
The source told Reuters an agreement had been reached on the contentious issue involving the league's proposal to create a pool of backup referees.
But while there has also been movement on the thorny matter of change to the referees' pension plans, the source said "economic gaps" remained and agreement had yet to be reached on how to grandfather in any new plan.
NFL spokesman Greg Aiello confirmed talks continued on Wednesday between the two sides, but he declined to comment on how the negotiations were progressing.
The NFLRA could not be reached for comment.
NFLRA referees have been locked out since June after failing to reach agreement with the league and club owners over a new Collective Bargaining Agreement.
Most of the replacements have been drawn from the lower ranks of college and high school football and semi-professional leagues and have struggled with the complex rules for NFL games.
After three weeks of games with replacement referees, outraged fans and players have ratcheted up complaints about the lockout, with much of the blame focused on the NFL and its management.
An opinion column in The New York Times by Thad Williamson, an associate professor of leadership studies at the University of Richmond, called on NFL Commissioner Roger Goodell to resign.
"He has failed in the first responsibility of any league commissioner, which is to safeguard the integrity and credibility of the game," wrote Williamson.
DISCIPLINARY ISSUES
The confusion on the field has led to a noticeable drop in discipline from players and coaches. New England Patriots head coach Bill Belichick was fined $50,000 by the league on Wednesday for grabbing an official by the arm at the end of his team's loss to the Baltimore Ravens on Sunday.
Players weighed in on the issue, with Cleveland Browns return specialist Josh Cribbs contrasting the league's behavior with its tight regulations of player conduct.
"It makes me angry because we're asked to do so much - pull our socks up, can't wear this, got do this," Cribbs told the Cleveland Plain Dealer.
"There are so many rules have to be upheld to. And who upholds the rules for them? Who holds the NFL accountable to maintain the integrity of the game?"
A more light-hearted take came from Green Bay, where channel NBC26 presented a bungling "Replacement Weather Guy," who forecast the weather would reach lows of minus-200 degrees F and highs of 346 degrees in Wisconsin.
In the Monday night game, Seattle beat Green Bay with a long "Hail Mary" pass on the final play. The replacement referees took more than 10 minutes to rule which team came down with the ball, and the NFL also said the next day that the crew missed an offensive pass interference that should have negated the play.
Despite fan complaints the inconsistent officiating was hurting the quality of play and the league's credibility, there has been no fall-off in gate attendance or TV viewership.
The Monday night matchup on Walt Disney Co cable network ESPN grabbed 16.2 million viewers, the most-watched program of the night, according to ratings tracker Nielsen.
Through the first three weeks of the season, "Monday Night Football" is averaging 13.4 million viewers, about even with last season, ESPN said.
Source: http://news.yahoo.com/1-nfl-refs-union-league-progress-talks-source-221326245--nfl.html
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Barnes & Noble launches new Nook HD
This undated image provided by Barnes & Noble shows one of the two new Nook tablets the company will be releasing in the fall of 2012. The company said Wednesday, Sept. 26, 2012, that its new Nook HD will come in two sizes, one with a screen 7-inches wide diagonally, the same size as past Nooks, starting at $199, and one with a new 9-inch diagonal screen, called the Nook HD+, starting at $269. In addition to the new HD screen and a lighter body, Barnes & Noble is also increasing the services the Nook offers. It is adding a video purchase and rental service, allowing user profiles and making it easier to browse titles in its book and magazine stores. (AP Photo/Barnes & Noble)
This undated image provided by Barnes & Noble shows one of the two new Nook tablets the company will be releasing in the fall of 2012. The company said Wednesday, Sept. 26, 2012, that its new Nook HD will come in two sizes, one with a screen 7-inches wide diagonally, the same size as past Nooks, starting at $199, and one with a new 9-inch diagonal screen, called the Nook HD+, starting at $269. In addition to the new HD screen and a lighter body, Barnes & Noble is also increasing the services the Nook offers. It is adding a video purchase and rental service, allowing user profiles and making it easier to browse titles in its book and magazine stores. (AP Photo/Barnes & Noble)
This undated image provided by Barnes & Noble shows one of the two new Nook tablets the company will be releasing in the fall of 2012. The company said Wednesday, Sept. 26, 2012, that its new Nook HD will come in two sizes, one with a screen 7-inches wide diagonally, the same size as past Nooks, starting at $199, and one with a new 9-inch diagonal screen, called the Nook HD+, starting at $269. In addition to the new HD screen and a lighter body, Barnes & Noble is also increasing the services the Nook offers. It is adding a video purchase and rental service, allowing user profiles and making it easier to browse titles in its book and magazine stores. (AP Photo/Barnes & Noble)
This undated image provided by Barnes & Noble shows one of the two new Nook tablets the company will be releasing in the fall of 2012. The company said Wednesday, Sept. 26, 2012, that its new Nook HD will come in two sizes, one with a screen 7-inches wide diagonally, the same size as past Nooks, starting at $199, and one with a new 9-inch diagonal screen, called the Nook HD+, starting at $269. In addition to the new HD screen and a lighter body, Barnes & Noble is also increasing the services the Nook offers. It is adding a video purchase and rental service, allowing user profiles and making it easier to browse titles in its book and magazine stores. (AP Photo/Barnes & Noble)
NEW YORK (AP) ? Barnes & Noble is rolling out two new versions of its Nook tablet with sleek new hardware and a sharper high-definition screen. The bookseller's move heightens the already intense tablet wars heading into the holiday season.
Barnes & Noble said Wednesday that its new Nook HD will come in two sizes, one with a 7-inch screen (measured diagonally), starting at $199, and one with a new 9-inch diagonal screen, called the Nook HD+, starting at $269.
In addition to the new HD screen and a lighter body, Barnes & Noble is also increasing the services the Nook offers, adding a video purchase and rental service, allowing users to maintain different "profiles" and making it easier to browse titles in its book and magazine stores.
New York-based Barnes & Noble, the largest traditional U.S. bookseller, has invested heavily in its Nook e-reader and e-books. In its most recent fiscal quarter, sales of digital content surged 46 percent, but revenue from devices dropped partly due to lower prices. Nook prices in the May-July period were about 23 percent lower than a year ago.
The company is seeking to offset tough competition from online retailers such as Amazon.com, as consumers increasingly move away from traditional books and DVDs to electronic books and streaming video.
The Nook HD is an upgrade to the hardware and services offered by its previous tablets, the Nook Tablet and Nook Color, which Barnes & Noble is phasing out. The company will continue to sell its smaller black-and-white e-reader, called the Nook Simple Touch, for $99, and a backlit Nook Simple Touch for $139. The Nook HD runs on Google's Android 4.0 system and includes Barnes & Noble's own app store and browser.
Tablets are ?once again? expected to be hot items this holiday. The new Nooks come on the heels of Amazon.com's announcement earlier this month that it will offer four new varieties of its Kindle, including a high definition version of its Kindle Fire tablet with an 8.9-inch diagonal screen, which starts at $299. That compares with Apple Inc.'s iPad with a 9.7-inch diagonal screen and $499 starting price.
Apple's iPad is the most popular tablet, and that is not expected to change. Seven out of every 10 tablets sold in the second quarter were iPads, according to IHS iSuppli. Meanwhile Amazon.com has a 4.2 percent share of the tablet market, while Barnes & Noble has a 1.9 percent share, according to iSuppli.
Even so, the category is growing rapidly. An estimated 112.5 million Americans, one-third of U.S. adults, are expected to have tablets by 2016, according to Forrester Research.
And tablet makers are jockeying to gain share on Apple. On specs alone, the new Nook presents a tough choice for consumers seeking a cheap option to the iPad this holiday, analysts say. The 7-inch Nook HD is slightly lighter and narrower, with a sharper display than the similarly priced 7-inch Kindle Fire.
"If the decision the consumer is making is whether to buy based on hardware, these new Nooks will beat out Amazon," said Forrester analyst James McQuivey. "But that's not the decision every consumer is going to make ? hardware is only as good as the services the hardware enables."
So far, Amazon offers more services, McQuivey said, with a bigger app store, and more extensive video library, not to mention Amazon's vast product offerings and its Amazon Prime free-shipping service.
In an attempt to measure up, Barnes & Noble is launching a video service this fall that lets users buy and watch movies and TV shows on their mobile devices and televisions. The offerings will come from major studios including HBO, Sony Pictures, Viacom and Warner Brothers. Scrapbook and catalog browsing features have also been added.
One wild card working in Barnes & Noble's favor this holiday: Wal-Mart Stores Inc. and Target, increasingly threatened by Amazon's online retail operations, won't carry the Kindle. The retailers will sell Barnes & Noble's Nooks, as well as other tablets like the iPad.
"This is going to be a lot of fun to watch over the next year," McQuivey said.
The new Nooks are available for pre-order online and in stores beginning on Wednesday and will begin shipping in late October and begin arriving in stores in early November.
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Mass. gov says he expects charges in lab scandal
Massachusetts Gov. Deval Patrick speaks with reporters in Cambridge, Mass., Thursday, Sept. 27, 2012. Patrick says he expects criminal charges will be brought in an investigation of misconduct by a state lab chemist who admitted faking drug sample results, forging signatures and skipping proper procedures. Patrick said he shut down the drug lab soon after learning of admissions chemist Annie Dookhan made during an interview with state police at the end of August. (AP Photo/Steven Senne)
Massachusetts Gov. Deval Patrick speaks with reporters in Cambridge, Mass., Thursday, Sept. 27, 2012. Patrick says he expects criminal charges will be brought in an investigation of misconduct by a state lab chemist who admitted faking drug sample results, forging signatures and skipping proper procedures. Patrick said he shut down the drug lab soon after learning of admissions chemist Annie Dookhan made during an interview with state police at the end of August. (AP Photo/Steven Senne)
Massachusetts Gov. Deval Patrick speaks with reporters in Cambridge, Mass., Thursday, Sept. 27, 2012. Patrick says he expects criminal charges will be brought in an investigation of misconduct by a state lab chemist who admitted faking drug sample results, forging signatures and skipping proper procedures. Patrick said he shut down the drug lab soon after learning of admissions chemist Annie Dookhan made during an interview with state police at the end of August. (AP Photo/Steven Senne)
Massachusetts Gov. Deval Patrick speaks with reporters in Cambridge, Mass., Thursday, Sept. 27, 2012. Patrick says he expects criminal charges will be brought in an investigation of misconduct by a state lab chemist who admitted faking drug sample results, forging signatures and skipping proper procedures. Patrick said he shut down the drug lab soon after learning of admissions chemist Annie Dookhan made during an interview with state police at the end of August. (AP Photo/Steven Senne)
BOSTON (AP) ? Massachusetts Gov. Deval Patrick said Thursday he expects criminal charges will be brought in an investigation of misconduct by a state lab chemist who admitted faking drug sample results, forging signatures and skipping proper procedures.
Speaking to reporters, Patrick said he shut down the drug lab soon after learning of admissions chemist Annie Dookhan made during an interview with state police at the end of August. The governor said he finds it troubling that Dookhan and her supervisors "did not seem to understand the gravity of this."
State police say Dookhan tested more than 60,000 drug samples covering 34,000 defendants during her nine years at the lab. She resigned in March during an internal investigation by the Department of Public Health, which ran the lab up until July 1, when state police took over as part of a state budget directive.
The scandal has thrown thousands of drug convictions into question. Already, judges have reduced bail and put sentences on hold in approximately 20 cases handled by Dookhan.
Dookhan's admissions were detailed in state police reports obtained Wednesday by The Associated Press.
When asked why Dookhan has not been arrested yet, Patrick referred to a criminal investigation being conducted by Attorney General Martha Coakley.
"I fully expect, and indeed I will say, I hope that there are charges, and I think that all of those who are accountable for the impact on individual cases need to be held accountable," Patrick said.
Coakley's spokesman, Brad Puffer, said the criminal investigation "remains active and ongoing."
"Our office provided the preliminary findings of our investigation to stakeholders so that immediate steps could be taken in the interest of justice," Puffer said.
Chemists who worked with Dookhan told investigators they had concerns about her work for several years, but they either convinced themselves they were invalid or reported them to supervisors who failed to intervene.
Dookhan admitted to investigators that she faked drug sample results for two to three years, according to the report.
Attorney Rosemary Scapicchio, who represents several defendants whose samples Dookhan handled, called for federal officials to take over the probe.
"I can't imagine she could have been this corrupt without someone noticing," she said. "The investigation needs to go deeper than Annie Dookhan to get to the point of 'How did she get away with it?'"
The state has created a central office to examine cases Dookhan was involved with and figure out how to deal with them.
After state police took over the lab they said they discovered her violations were much more extensive than previously believed and went beyond sloppiness into deliberate evidence mishandling.
Supervisors suspended Dookhan's lab duties in June 2011, when she was caught forging a colleague's initials on paperwork after taking 90 drug samples from evidence, according to police. But she told police later she disobeyed orders and continued to access an evidence database and give law enforcement officials information on their cases.
On Aug. 30, Gov. Deval Patrick ordered state police to close the lab.
That day, a police lieutenant spoke with Dookhan to tell her she should get an attorney because she could face criminal charges.
Dookhan cried on the phone. She said she was involved in a long divorce from her husband, didn't have money and didn't know any lawyers.
Anne Goldbach from Committee for Public Counsel Services, which oversees legal representation for indigents, said the interviews included in the police report show the problems at the now-closed Hinton State Laboratory are more troubling than originally believed. She said it appears there was unsupervised access to the evidence office and safe.
Goldbach said because Dookhan was in charge of quality control equipment, other chemists could have gotten false test results without knowing it.
"It calls into question all the testing done by the lab," she said.
Attorney John T. Martin said Wednesday that he noticed a pattern of suspicious behavior from Dookhan while looking over his clients' cases.
He said in four cases, Dookhan determined the weight of the drug sample was just 1 gram above the amount needed for a more serious penalty even though police reports made the seizure seem smaller.
Concerns from Dookhan's colleagues prompted two supervisors to audit her work in 2010, but they just looked at paperwork and didn't retest drug samples.
Things started to unravel in spring 2011 with the forging incident. A colleague told police it was "almost like Dookhan wanted to get caught."
One lab supervisor told police later that he believed Dookhan had a mental breakdown.
Dookhan told investigators several times in an August interview that she knew she had done wrong.
"I screwed up big time," she said, according to the report from investigators for Attorney General Martha Coakley's office. "I messed up bad. It's my fault. I don't want the lab to get in trouble."
Authorities haven't commented on Dookan's possible motives as their probe continues. She hasn't responded to repeated requests for comment.
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OUPblog ? Blog Archive ? Just what is triple-negative breast cancer?
By Patricia Prijatel
The big news this week comes from the Cancer Genome Atlas program, which has announced a strong molecular connection between basal-like breast cancer tumors and ovarian cancer. The news stories I have read on the topic provide a great deal of hope for women with basal-like cancers. But the hope is, unfortunately, buried in a greater deal of confusion.
Here?s the hope: We?re getting closer and closer to understanding what makes breast cancer tick on a molecular level, and that means we could ultimately have treatments that target specific molecular anomalies, making the treatment more effective, efficient, and possibly less toxic. Most important, it would be clearer to doctors which patients need chemo and which don?t, saving thousands of people from unnecessary and dangerous treatment. And making chemo for those who need it more precise.
Among those who could benefit most from this research are the women and men with triple-negative breast cancer (TNBC), which is currently treated with anthracylines ? chemotherapy drugs such as Cytoxan and Adriamycin ? that can cause long-term side effects including heart disease and increased risk of leukemia. Moreover, metastatic TNBC ? cancer that has spread beyond to distant organs ? can be resistant even to current forms of chemo.
The research on the genome project, published in the 23 September 2012 online edition of the journal Nature, ties basal-like breast cancers to ovarian cancers on a molecular level, suggesting that ultimately TNBC could be treated with the less-toxic chemotherapy used for ovarian cancer, including a mix of a carboplatin (Paraplatin) or cisplatin with a taxane such as paclitaxel (Taxol) or docetaxel (Taxotere).
That?s the hope. Now the confusion. The biggest confusion revolves around our understanding of triple-negative breast cancer (TNBC).
Some news stories I have read equate TNBC with basal-like tumors, as though the two were synonymous, which is not accurate. There is a correlation between TNBC and basal-like cancers, but not all TNBC tumors are basal-like, and not all basal-like tumors are TNBC. In fact, some researchers break TNBC into three subtypes, including basal-like and non-basal-like.
The other, and bigger, problem, come in the terms journalists and researchers use for TNBC: ?particularly deadly,? ?especially aggressive,? and ?lethal.?
I understand why these words are used; it makes the research appear more significant. But these terms can frighten and depress those with TNBC and their families, and the research is significant enough to stand on its own without hyperbole.
Lost in the hyperbole is the fact that most women survive TNBC. The rates depend on too many factors to offer a generalization, but multiple studies have shown from 70 to 90% of patients with TNBC with no recurrence after five years. And rates for TNBC recurrence drop significantly after three years, so TNBC patients who have reached five years without recurrence often face better long-term odds than those with other forms of breast cancer.
It is a disease to take seriously, but who doesn?t take cancer seriously? Patients and survivors don?t need frightening words for effect. They are frightened enough.
Triple-negative breast cancer gets its name because tumors of this subtype lack receptors for estrogen, progesterone, and the human growth hormone Her2/neu. The significance of being negative for these receptors is that TNBC lacks a targeted therapy, such as tamoxifen, which blocks the effects of estrogen, Arimidex, which prevents the production of estrogen, and Herceptin, which treats her/2-positive tumors.
So, TNBC is a disease defined by what it lacks. But, thanks to research on the human genome, it may soon be defined by its specific molecular characteristics. And treating something you can define is a whole lot easier than treating what you can?t.
Patricia Prijatel is author of Surviving Triple-Negative Breast Cancer, published by Oxford University Press. She is the E.T. Meredith Distinguished Professor Emerita of Journalism at Drake University. She is doing a webcast with the Triple Negative Breast Cancer Foundation on 16 October 2012.
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Source: http://blog.oup.com/2012/09/what-is-triple-negative-breast-cancer/
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Wednesday 26 September 2012
French government asks Facebook to explain data glitch
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