Friday, 10 May 2013

New discovery may lead the way to improved whooping cough vaccine

May 10, 2013 ? Scientists at Trinity College Dublin have made novel discoveries concerning the current vaccine against whooping cough that may lead to the development of an improved future vaccine. The findings could help reduce the incidence of the disease which is increasing in developed countries. The research led by Professor of Experimental Immunology, Kingston Mills has just been published in the journal PLoS Pathogens.

A new vaccine against whooping cough, caused by the bacteria Bordetella pertussis was first introduced to the routine vaccination schedule for infants and children in most developed countries, including Ireland over a decade ago. Prior to the introduction of this vaccine, children were immunised with a vaccine made from whole bacteria. Although this 'whole cell pertussis vaccine' was effective at preventing the infection, it had been associated with side effects. Dissatisfaction with that vaccine led to the development of an 'acellular pertussis vaccine' made from components of the bacteria combined with an adjuvant to boost immune responses.

Following its introduction in the late 1990s, the new vaccine has proved to be very safe and has been effective in controlling the potentially fatal disease of whooping cough in children. However, protective immunity conferred with the vaccine falls quite quickly, necessitating frequent booster vaccinations. This fall off in the immunity may be contributing to the number of whooping cough cases which are increasing with quite dramatic increases reported in certain countries, including the US, Australia and the Netherlands.

Professor Kingston Mills's research team at the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute has discovered important mechanistic differences in the type of immune responses induced with the new 'acellular' and old 'whole cell' vaccine. The whole cell vaccine, although much more likely to cause adverse reactions in recipients, was capable of inducing strong cellular immune responses mediated by white blood cells called T cells, in particular a type of T cell called Th1 cells. In contrast, the new acellular vaccine, although safer, was less effective in inducing cellular immunity, but instead induced immunity mediated by antibodies and another type of T cell called a Th17 cell.

Most vaccines include a component called an adjuvant to boost immune responses to the bacterial or viral antigens in the vaccine and the acellular pertussis vaccine uses an aluminium salt, called alum. However, Dr Padraig Ross, Dr Sarah Higgins and Ms Aideen Allen in Professor Mills' laboratory, working in collaboration with Dr Rachel McLoughlin and Dr Ed Lavelle, have shown that the vaccine could be improved further through the use of a different adjuvant.

The current vaccine does not enhance the induction of Th1 cells, required for conferring optimum protective immunity against the bacteria. They showed that by switching the adjuvant from alum to an adjuvant based on bacterial DNA, they could induce the crucial Th1 cells and thereby enhance the efficacy of the vaccine against Bordetella pertussis infection in a murine model. The new vaccine has the potential to protect a higher proportion of immunised children using a lower number of doses.

Commenting on the significance of the findings, Professor Mills said: "Although it will not be an easy task to implement, our findings should pave the way for an improved vaccine against whooping cough in children."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/sad3XlnB4jc/130510124457.htm

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Thursday, 9 May 2013

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Eduardo Galeano on Writing, "Historical Amnesia" in Latin America & His Fight Against Cancer

Eduardo Hughes Galeano (born September 3, 1940) is a Uruguayan journalist, writer and novelist. His best known works are Memoria del fuego (Memory of Fire Trilogy, 1986) and Las venas abiertas de Am?rica Latina (Open Veins of Latin America, 1971) which have been translated into twenty languages and transcend orthodox genres: combining fiction, journalism, political analysis, and history. The author himself has proclaimed his obsession as a writer saying, "I'm a writer obsessed with remembering, with remembering the past of America above all and above all that of Latin America, intimate land condemned to amnesia."[1]

Galeano was born in Montevideo, Uruguay to a middle class Catholic family of European descent (Italian, Spanish, German and British descent). Like many young Latin American boys, Galeano dreamed of becoming a football (soccer) player; this desire was reflected in some of his works, such as El F?tbol A Sol Y Sombra (Football In Sun and Shadow). In his teens, Galeano worked odd jobs ? as a factory worker, a bill collector, a sign painter, a messenger, a typist, and a bank teller. At 14 years, Galeano sold his first political cartoon to the Socialist Party weekly, El Sol and married for the first time in 1959. He started his career as a journalist in the early 1960s as editor of Marcha, an influential weekly journal which had such contributors as Mario Vargas Llosa, Mario Benedetti, Manuel Maldonado Denis and Roberto Fern?ndez Retamar. For two years he edited the daily ?poca and worked as editor-in-chief of the University Press. In 1962, having divorced, he remarried to Graciela Berro.

In 1973, a military coup took power in Uruguay; Galeano was imprisoned and later was forced to flee. His book Open Veins of Latin America was banned by the right-wing military government, not only in Uruguay, but also in Chile and Argentina.[2] He settled in Argentina where he founded the cultural magazine, Crisis. In 1976 he married for the third time to Helena Villagra, however in the same year the Videla regime took power in Argentina in a bloody military coup and his name was added to the lists of those condemned by the death squads. He fled again, this time to Spain, where he wrote his famous trilogy: Memoria del fuego (Memory of Fire).

At the beginning of 1985 Galeano returned to Montevideo, where he continues to live. Following the victory of Tabar? V?zquez and the Broad Front alliance in the 2004 Uruguayan elections marking the first left-wing government in Uruguayan history Galeano wrote a piece for The Progressive titled "Where the People Voted Against Fear" in which Galeano showed support for the new government and concluded that the Uruguayan populace used "common sense" and were "tired of being cheated" by the traditional Colorado and Blanco parties.[3] Following the creation of TeleSUR, a pan-Latin American television station based in Caracas, Venezuela, in 2005 Galeano along with other left-wing intellectuals such as Tariq Ali and Adolfo P?rez Esquivel joined the network's 36 member advisory committee.[4]

In 2006, Galeano signed a petition in support of the independence of Puerto Rico from the United States of America.

On February 10, 2007, Galeano underwent a successful operation to treat lung cancer.[5] During an interview with journalist Amy Goodman following Barack Obama's election as President of the United States in November 2008, Galeano said, "The White House will be Barack Obama's house in the time coming, but this White House was built by black slaves. And I?d like, I hope, that he never, never forgets this."[6] At the April 17, 2009, opening session of the 5th Summit of the Americas held in Port of Spain, Trinidad and Tobago, Venezuelan President Hugo Chavez gave a copy of Galeano's Open Veins of Latin America to U.S. President Barack Obama, who was making his first diplomatic visit to the region.[7] This made the English language edition of the book go to #2 position and the Spanish version to #11 on the Amazon.com bestseller list.

In a May 2009 interview he spoke about his past and recent works, some of which deal with the relationships between freedom and slavery, and democracies and dictatorships; "... not only the United States, also some European countries, have spread military dictatorships all over the world. And they feel as if they are able to teach democracy...". He also talked about how and why he has changed his writing style, and his recent rise in popularity.[8]

"Fleas dream of buying themselves a dog, and nobodies dream of escaping poverty: that, one magical day, good luck will suddenly rain down on them - will rain down in buckets. But good luck doesn?t rain down, yesterday, today, tomorrow or ever. Good luck doesn?t even fall in a fine drizzle, no matter how hard the nobodies summon it, even if their left hand is tickling, or if they begin the new day on their right foot, or start the new year with a change of brooms. The nobodies: nobody?s children, owners of nothing. The nobodies: the no-ones, the nobodied, running like rabbits, dying through life, screwed every which way. Who are not, but could be. Who don?t speak languages, but dialects. Who don?t have religions, but superstitions. Who don?t create art, but handicrafts. Who don?t have culture, but folklore. Who are not human beings, but human resources. Who do not have faces, but arms. Who do not have names, but numbers. Who do not appear in the history of the world, but in the crime reports of the local paper. The nobodies, who are not worth the bullet that kills them."

? Eduardo Galeano, "The Nobodies" [9]

Las venas abiertas de Am?rica Latina (Open Veins of Latin America) is arguably Galeano's best-known work. In this book, he analyzes the history of Latin America as a whole from the time period of European contact with the New World to contemporary Latin America arguing against the European and later U.S. economic exploitation and political dominance over the region. It was the first of his many books to be translated by Cedric Belfrage into English. It is a classic among scholars of Latin American history. The book gained popularity in the English-speaking world after the Venezuelan President Hugo Chavez gave it as a gift to the American President Barack Obama.

Memoria del fuego (Memory of Fire) is a three-volume narrative of the history of America, North and South. The characters are historical figures; generals, artists, revolutionaries, workers, conquerors and the conquered, who are portrayed in brief episodes which reflect the colonial history of the continent. It starts with pre-Columbian creation myths and ends in the 1980s. It highlights not only the colonial oppression that the continent underwent but particularly the long history of resistance, from individual acts of heroism to mass revolutionary movements.

Memoria del fuego is widely praised by reviewers. Galeano was compared to John Dos Passos and Gabriel Garc?a M?rquez. Ronald Wright wrote in the Times Literary Supplement: "Great writers... dissolve old genres and found new ones. This trilogy by one of South America's most daring and accomplished authors is impossible to classify."

In New York Times Book Review Jay Parini praised as perhaps his most daring work The Book of Embraces, a collection of short, often lyrical stories presenting Galeano's views on emotion, art, politics, and values, as well as offering a scathing critique of modern capitalistic society and views on an ideal society and mindset. (The Book of Embraces was the last book Cedric Belfrage translated before he died in 1991.)

Galeano is also an avid soccer fan; in his childhood, Galeano had the dream of becoming a soccer player and this desire is the subject of some of his writings, among them Soccer in Sun and Shadow (1995), a review of the history of the game. Galeano compares it with a theater performance and with war; he criticizes its unholy alliance with global corporations but attacks leftist intellectuals who reject the game and its attraction to the broad masses for ideological reasons.

Galeano's Espejos (Mirrors) is Galeano's most expansive work since Memory of Fire. Galeano offers a broad mosaic of history told through the voices of the unseen, unheard, and forgotten. Recalling the lives of artists, writers, gods and visionaries, Galeano's makes "lore out of the mass of history and stories that make this world, and make us human." (Rick Simonson) Mirrors was published in the US in English by Nation Books in June 2009.

Galeano is a regular contributor to The Progressive and the New Internationalist, and has also been published in the Monthly Review and The Nation.

  1. ^ Mark your calendars...... Octopus Books
  2. ^ Fresh Off Worldwide Attention for Joining Obama?s Book Collection, Uruguayan Author Eduardo Galeano Returns with "Mirrors: Stories of Almost Everyone".
  3. ^ Eduardo Galeano, "Where the People Voted Against Fear" January 2005 The Progressive
  4. ^ Alfonso Daniels, "'Chavez TV' beams into South America" July 26, 2005 The Guardian
  5. ^ Eduardo Galeano se recupera de operaci?n El Universal, 11 February 2007 (Spanish)
  6. ^ Interview with Amy Goodman on Democracy Now!, November 5, 2008 (video, audio, and print transcript)
  7. ^ The Washington Times
  8. ^ Audio and transcript of interview, May 2009
  9. ^ Pathologies of Power: Health, Human Rights, and the New War on the Poor, by Paul Farmer, University of California Press, ISBN 0-520-24326-9, pg 1
  • Interview with Eduardo Galeano
  • Eduardo Galeano, "The Devil's Devils" (Trans. Mark K. Jensen), Le Monde diplomatique, no. 617 (August 2005), p.?10.
  • Sandra Cisneros reads "Los Nadies/The Nobodies" by Eduardo Galeano from Book of Embraces, El libro de los abrazos (1989) "[1]".
  • "'Voices of Time': Legendary Uruguayan Writer Eduardo Galeano on Immigration, Latin America, Iraq, Writing ? and Soccer," Democracy Now! 19 May 2006
  • "Reflections from Eduardo Galeano," The Leonard Lopate Show, 19 May 2006.
  • "Writer Without Borders" -- interview by Scott Widmer on In These Times
  • "Author of the Month," Escritores.org
  • Eduardo Galeano Articles Third World Traveler
  • The Guardian: Ch?vez creates overnight bestseller with book gift to Obama
  • Eduardo Galeano Interviewed by Jonah Raskin by Monthly Review, October 2009
  • Uruguayan Author Eduardo Galeano Returns with Mirrors: Stories of Almost Everyone - video report by Democracy Now!
  • Haiti Occupied Country
Persondata
Name Galeano, Eduardo
Alternative names
Short description
Date of birth September 3, 1940
Place of birth Montevideo,
Date of death
Place of death

Source: http://article.wn.com/view/2013/05/08/Eduardo_Galeano_on_Writing_Historical_Amnesia_in_Latin_Ameri/

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Five questions with? Joseph Willis, Bloomingdale High basketball coach

Published: May 8, 2013

This week we chat with Joseph Willis, 37, boys basketball coach at Bloomingdale High School for the past four years.

Last night, he took part in the school?s annual student-faculty basketball game. The game was part of a weekend full of activities to benefit Bell Shoals Beef ?O? Brady?s server Kim Camille and husband Roger, who was recently diagnosed with lymphoma for a second time.

Where did the idea for the student-faculty basketball game come from?

Before I came to Bloomingdale, I had heard about other schools having charity basketball games to support some great causes. So when I arrived here, I was really excited about rallying our students and teachers together to do something for this terrific school and community. ??

What are some of the organizations and people the game has helped in previous years?

In years past, proceeds have gone towards pediatric cancer and an organization called Lyrics For Life (formed by musical band Sister Hazel). Cormac McCarthy, owner of the Bloomingdale and Fishhawk Beef ?O? Brady's and ultra-supporter of our basketball and athletic programs here at Bloomingdale, recommended this group. ?

What are your goals for the Bloomingdale High basketball team next season?

Our goals are always to improve and work hard in everything we do. We are always striving to get better athletically, academically, and with our character. We were very young this past season and now these guys are more experienced. I expect a lot from them this coming season.

Who is your all-time favorite basketball player?

Michael Jordan. He reminds me of how I used to play (Students, take note). I'm kidding of course. I liked the entire Chicago Bulls teams from that era. Jordan, Pippen, Grant, Paxson ? they all played as a team.

Who do you see meeting in this year?s NBA Finals, and who comes out on top?

I think the Heat are really good and should win it. The Spurs are also very good and have the edge out west now that (Oklahoma City?s) Russell Westbrook has gone down. I don't watch much NBA since I am a college guy, but I'm always impressed with how good those guys are.

John Ceballos


Source: http://feedproxy.google.com/~r/tbo/brandon/~3/2xCDY5bn6kw/five-questions-with-joseph-willis-bloomingdale-high-basketball-coach-b82489379z1

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Tuesday, 30 April 2013

Marissa Mayer Explains Yahoo's New Approach To Advertising ...

Owen Thomas, Business Insider

Yahoo CEO Marissa Mayer at the 2013 Goldman Sachs Technology and Internet Conference

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Yahoo CEO Marissa Mayer has a new plan for generating more ad revenue.

Today she announced two new types of ads: Yahoo! Stream Ads and a new interactive Billboard ad.

This is all part of the big redesign that Yahoo launched in February, Mayer says. That's when Yahoo changed its front page into a streaming headline format, eliminating several ad units and letting people customize the page in new ways.

Today she's added some ad units back to the page. As its name implies the Stream ad will be embedded into the news stream of a user's home page. It will show up across devices like desktops/laptops, smartphones, and tablets.

It looks like this:

Yahoo

Yahoo Stream ad is the text in the yellow box

The Billboard unit will look like a fairly traditional banner ad that sits on top of the Yahoo page. Mayer says that it is different because it will ink to content that's more "fun and engaging" for Yahoo visitors.

The first Stream ads could start showing up as soon as this week.

Here's her full blog post:

As we continue to build products and features that inspire and entertain our users, we're committed to delivering engaging and effective advertising opportunities. Over the past few months, we?ve begun to evolve the Yahoo! experience to be more personal, intuitive, and immersive -- incorporating more modern paradigms like our news stream. Today, we?re matching that engaging stream experience with a new advertising format -- Yahoo! Stream Ads.

Since we launched our Yahoo! news stream in February, our users have responded by visiting more, staying longer, and increasing their engagement with our content. Like with web search, users appreciate complementary, unobtrusive advertising, and we?re committed to delivering just that. Advertising can, and should, enhance content discovery in a seamless and effective manner. The more our users spend time with Yahoo!, the more relevant and personalized the content and advertising becomes. Stream Ads are the sponsored twin to our newsfeed articles and are every bit as personalized and engaging.

Today, we?re also announcing a new Yahoo.com Billboard designed to deliver richer content interactions to Yahoo! users. For example, a movie trailer that runs on the Billboard could link to more information about the film and cast, and let you buy tickets directly from the ad. We believe that advertising like this can be fun and engaging for users, while also effective for advertisers.

Going forward, we?re committed to advertising formats that complement our products and content, and enhance the user experience. Stay tuned for more in the coming months!

Source: http://www.businessinsider.com/marissa-mayer-explains-yahoos-new-approach-to-advertising-2013-4

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World War II vet who provided flag at Iwo Jima dead at 90

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AP Photo/Joe Rosenthal, File

This Feb. 23, 1945 file photo shows U.S. Marines of the 28th Regiment, 5th Division, raising the American flag atop Mt. Suribachi in Iwo Jima, Japan. Alan Wood, a World War II veteran who provided the flag in the famous flag-raising on Iwo Jima has died. Alan Wood was 90. Wood was in charge of communications on a landing ship on Iwo Jima's shores when a Marine asked him for the biggest flag that he could find. Wood handed him a flag he had found in Pearl Harbor.

By The Associated Press

A veteran of World War II credited with providing the flag in the famous flag-raising on Iwo Jima has died at his Los Angeles County home. Alan Wood died of natural causes April 18 at the age of 90, his son Steven Wood announced Saturday.


Wood was a 22-year-old Navy officer in charge of communications on a landing ship on Iwo Jima's shores on Feb. 23, 1945 when a Marine asked him for the biggest flag he could find.

After five days of intense fighting to capture the Japanese-held island, U.S. forces had managed to scale Mount Suribachi to hoist an American flag. Woods happened to have a 37-square-foot flag that he had found months before in a Pearl Harbor Navy depot.

Five Marines and a Navy Corpsman raised the flag in a stirring moment captured by Associated Press photographer Joe Rosenthal. Steven Wood said his father was always humbled by his small role in the historic moment.

In a 1945 letter to a Marine general who asked for details about the flag, Alan Wood wrote: "The fact that there were men among us who were able to face a situation like Iwo where human life is so cheap, is something to make humble those of us who were so very fortunate not to be called upon to ensure such hell."

In a story on Wood's death, the Los Angeles Times reported that over the years others have claimed that they provided the famous Iwo Jima flag, but retired Marine Col. Dave Severance, who commanded the company that took Mount Suribachi, said in an interview last week that it was Wood.

"I have a file of more than 60 people who claim to have have something to do with the flags," Severance said from his home in La Jolla, Calif.

After the war, Wood went on to work as a technical artist and spokesman at the Jet Propulsion Laboratory in La Canada Flintridge.

His wife, Elizabeth, died in 1985. Besides his son, Wood is survived by three grandchildren.

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? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2b46191f/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A40C280C179572270Eworld0Ewar0Eii0Evet0Ewho0Eprovided0Eflag0Eat0Eiwo0Ejima0Edead0Eat0E90A0Dlite/story01.htm

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Lawyers, public chant "hang him" as Bangladesh building owner led to court

By Ruma Paul and Serajul Quadir

DHAKA (Reuters) - Bangladeshi lawyers and protesters chanted "hang him, hang him" on Monday as the owner of a factory building that collapsed last week killing nearly 400 people was led into court dressed in a helmet and bullet-proof jacket, witnesses said.

The drama came as rescue officials said they were unlikely to find more survivors in the rubble of the building that collapsed on Wednesday, burying hundreds of garment workers in the country's worst industrial accident.

Heavy cranes were being used to lift huge concrete blocks from the wreckage of Rana Plaza, where 385 people are now confirmed to have been killed. The building housed factories making clothes for Western brands.

Eight people have been arrested - four factory bosses, two engineers, building owner Mohammed Sohel Rana and his father, Abdul Khalek. Police are looking for a fifth factory boss, David Mayor, who they said was a Spanish citizen.

Rana, a local leader of the ruling Awami League's youth front, was shown on television being brought to Dhaka in handcuffs after he was seized in the border town of Benapole by the elite Rapid Action Battalion following a four-day manhunt.

Rana was arrested by police commandos on Sunday, apparently trying to flee to India.

"Put the killer on the gallows, he is not worth of any mercy or lenient penalty," one onlooker outside the court shouted.

The court ordered that Rana be held for 15 days "on remand" for interrogation.

Khalek, who officials said was named in documents as a legal owner of the building, was arrested in Dhaka on Monday. Those being held face charges of faulty construction and causing unlawful death.

Bangladesh does carry out the death penalty for murder and for most serious categories of manslaughter.

Hundreds of the mostly female workers who are thought to have been inside the building when it caved in remain unaccounted for. A fire overnight further hampered the last desperate efforts to find survivors.

"We are giving the highest priority to saving people, but there is little hope of finding anyone alive," army spokesman Shahinul Islam told reporters at the site.

About 2,500 people have been rescued from the wrecked building in the commercial suburb of Savar, about 30 km (20 miles) from the capital, Dhaka.

Late on Sunday, sparks from rescuers' cutting equipment started a fire in the debris as they raced to save a woman who may have been the last survivor in the rubble. Her body was recovered on Monday afternoon.

"We could not save her, even though we heard her voice this morning," a tearful rescue worker told reporters at the scene.

Officials said the eight-storey complex had been built on swampy ground without the correct permits, and more than 3,000 workers - most of them young women - entered the building on Wednesday morning despite warnings that it was structurally unsafe.

A bank and shops in the same building closed after a jolt was felt and cracks were noticed on some pillars on Tuesday.

The collapse was the third major industrial incident in five months in Bangladesh, the second-largest exporter of garments in the world behind China. In November, a fire at the Tazreen Fashion factory in a suburb of Dhaka killed 112 people.

Such incidents have raised serious questions about worker safety and low wages in the poor South Asian country, which relies on garments for 80 percent of its exports. The industry employs about 3.6 million people, most of them women, some of whom earn as little as $38 a month.

In a development that may raise questions about the authorities' handling of the rescue operation, a spokesman at the British High Commission on Monday confirmed that an offer of technical assistance from Britain had been declined.

Anger over the disaster has sparked days of protests and clashes, and paramilitary troops were deployed in the industrial hub of Gazipur as garment workers took to the streets again on Monday, smashing cars and setting fire to an ambulance.

The unrest forced authorities to shut down many factories, which had reopened on Monday after two days of closures. Police fired teargas to disperse protesters.

The main opposition has called for a national strike on May 2 in protest over the incident.

Emdadul Islam, chief engineer of the state-run Capital Development Authority, said last week that Rana had not received the proper construction consent for the building, and had illegally added three stories to the original five.

(Writing by Alex Richardson and Nick Macfie)

Source: http://news.yahoo.com/little-hope-more-survivors-bangladesh-toll-nears-400-080033210.html

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