In studies, heart disease, neurological disorders and other degenerative diseases, scientists are moving away from the nature and nurture debate, and discover that you?re not a creature is genetic or environmental, but two ? with enormous implications for a new approach to health .Dashwood, who is also head of the IPM program Chemoprotection cancer, will present some of this research in a speech titled metabolism as a key to HDAC inhibition by dietary constituents, at the annual meeting of the American Society for Biochemistry and Molecular Biology of. The conference will be held at the Anaheim Convention Center Ballroom and Wednesday, April 28th at 13:30 PST.
According to Rod Dashwood, a professor of environmental toxicology and molecular biology at the Linus Pauling Institute at Oregon State University, epigenetics is a unifying theory, in which many health problems ranging from cancer to cardiovascular disease and neurological disorders, can be caused, at least in part altered histone modifications, and their effects on the reading of DNA in cells.
Some therapeutic drugs already used for cancer treatment in a clinical setting will probably work, at least in part, because they act as HDAC inhibitors, said Dashwood. And what is most intriguing is that HDAC inhibition may affect many degenerative health problems, not just cancer. Heart disease and even aging may have ties with altered HDAC / histone.
Metabolism seems to be a key factor, even the generation of HDAC active site of action, said Dashwood. In cancer cells, p21 tumor suppressors such as p53 and often become epigenetically silence. HDAC inhibitors can help you turn, makeup and cancer cells to commit suicide by apoptosis.
The new field of epigenetics is rapidly revealing how people, plants and animals begin with a certain genetic code at conception. But the choice of which genes are expressed or activated, is strongly influenced by environmental factors. Gene expression can change very rapidly over time, can be influenced by external factors, these changes can be transmitted to offspring, and can literally the key to life and death.
The study?s lead author Peter Cram, MD, associate professor of the user interface of Internal Medicine, found that large hospitals may be a relatively high incidence of orthopedic surgery, but often were classified as less specialized, as do many other types of orthopedic surgery at the outside.
The good news ? for cancer and perhaps many other health problems ? is that HDAC inhibitors can stop this degenerative process, and some of them have already been identified in foods are common examples. sulforaphane in broccoli, indole-3-carbinol in cruciferous vegetables, and organic compounds in vegetables such as garlic and onion. butyrate, a compound produced in the intestine when dietary fiber is fermented, is an HDAC inhibitor, and provides a possible explanation for why higher intake of dietary fiber may help prevent cancer.
We believe that many diseases that have aberrant expression of the gene to their roots can be linked to how DNA is packaged, and actions of enzymes such as histone deacetylases, or HDACs, Dashwood said. Not later than 10 years ago we knew almost nothing about the interruption of HDAC in cancer or other diseases, but is now one of the most promising areas of health research.
We already know that some of the things people can do to help prevent cancer with certain dietary approaches or lifestyle, said Dashwood. Now we hope to better understand the molecular processes in progress, even in epigenetics.
This should open the door to new approaches to disease prevention or treatment through diet, and to complement conventional drug therapies.
Source: http://www.whitmoremansion.com/epigenetics-concepts-offers-new-approach-to-degenerative-disease.html
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